Protocol for Topology-preserving Smoothing of BOLD fMRI Retinotopic Maps of the human visual cortex

Yanshuai Tu*, Xin Li*, Zhong-Lin Lu, Yalin Wang


The hierarchical organization of the visual system results in topology, which often gets lost in the “raw” human retinotopic maps derived from BOLD fMRI recordings. Here, we present the protocol for generating topology-preserving and smooth retinotopic maps from human retinotopy fMRI data. We describe data pre-processing, 3D surface flattening, and selection of the region of interest (ROI), followed by smoothing of the retinotopic map within the ROI. This approach can be applied to visual cortex V1, V2 and V3 simultaneously. 

For complete details on the use and execution of this protocol, please refer to Tu et al. (2021).

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